For more information, please contact either listing below:

Prospect Medical Holdings, Inc.
Linda Hodges,
Executive Vice President
(310) 337.4170
linda.hodges@prospectmedical.com

Investor Relations Counsel:
The Equity Group Inc.
Devin Sullivan
(212) 836-9608
dsullivan@equityny.com

FOR IMMEDIATE RELEASE

PROSPECT MEDICAL HOLDINGS TO PRESENT AT ROTH CAPITAL PARTNERS 18TH ANNUAL OC CONFERENCE

Culver City, CA— February 16, 2006— Prospect Medical Holdings, Inc. (AMEX: PZZ) ("Prospect Medical"), which manages the medical care of individuals enrolled in managed care (HMO) plans in southern California, today announced that it is scheduled to present at the Roth Capital Partners 18th Annual OC Conference on Wednesday, February 22, 2006 at 1:00 PM Pacific Time / 4:00 pm Eastern Time. The conference is being held at the St. Regis Monarch Beach Resort & Spa in Dana Point, CA.

Investors can access the live presentation and view a copy of the slide presentation via the home page of Prospect Medical's website at www.prospectmedicalholdings.com. Interested parties should go to the website at least 15 minutes early to register, download and install any necessary audio software. You can also access the webcast and replay at http://www.wsw.com/webcast/roth7/pzz/.

ABOUT THE COMPANY

Prospect Medical Holdings, Inc. is a health care management services organization that provides management services primarily to its affiliated IPAs. IPAs are professional corporations that contract with independent physicians and other health care providers to create a medical panel of primary care and specialist physicians, and other health care service providers, capable of providing the full range of medical services to individuals enrolled in health maintenance organization ("HMO") managed care health plans. At December 31, 2005, Prospect's IPAs were comprised of approximately 9,000 primary care and specialist physicians serving approximately 184,400 HMO enrollees.

The presentation noted within this press release may contain forward-looking statements. Additional written or oral forward-looking statements may also be made by the Company from time to time, in filings with the Securities and Exchange Commission, or otherwise. Statements contained in such presentations that are not historical facts are forward-looking statements. Investors are cautioned that forward-looking statements, including the statements regarding anticipated or expected results, involve risks and uncertainties which may affect the Company's business and prospects, including those outlined in the Company's Form 10-K filed on December 27, 2005 and in the Form 10-Q filed on February 14, 2006. Any forward-looking statements that might be contained in the presentation represent our estimates only as of the date hereof, or as of such earlier dates as are indicated, and should not be relied upon as representing our estimates as of any subsequent date. While we may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if our estimates change.